Dr. No features three orphans!
James Bond orphaned at 11 yrs old. His parents were killed in a mountain climbing accident
Honey Rider orphaned at age 5, when her parents' house was burnt down.
Dr. No was the unwanted son of a German missionary & a Chinese girl of good family. In the film, James Bond is sent to Jamaica to investigate the disappearance of a fellow British agent. The trail leads him to the underground base of Dr. Julius No, who is plotting to disrupt an early American space launch from Cape Canaveral with a radio beam weapon.